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The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile

It is derived from a naturally occurring protective gastric protein, contains 15 amino acids (hence pentadecapeptide), and demonstrates unusual stability under experimental conditions compared with many other peptides

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The pathological manifestations of HT are often lymphocyte infiltration, follicular cell atrophy and glandular fibrosis